General John Forbes finally took the forks in 1758.
Forbes began construction on Fort Pitt, named after William Pitt the Elder while the settlement was named "Pittsborough".
The city features 30 skyscrapers, two inclined railways, a pre-revolutionary fortification and the Point State Park at the confluence of the rivers.
The city developed as a vital link of the Atlantic coast and Midwest, as the mineral-rich Allegheny Mountains made the area coveted by the French and British empires, Virginians, Whiskey Rebels, and Civil War raiders.
The nation's eighth-largest bank, eight Fortune 500 companies, and six of the top 300 U. law firms make their global headquarters in the area, while RAND, BNY Mellon, Nova, Fed Ex, Bayer and NIOSH have regional bases that helped Pittsburgh become the sixth-best area for U. Michael Bezallion was the first to describe the forks of the Ohio in a 1717 manuscript, and later that year European fur traders established area posts and settlements.
During 1753–54, the British hastily built Fort Prince George before a larger French force drove them off.
Fort Pitt is notable as the site of an early use of smallpox for biological warfare.During this period, the powerful nations of the Iroquois Confederacy, based in New York, had maintained control of much of the Ohio Valley as hunting grounds by right of conquest after defeating other tribes.By the terms of the 1768 Treaty of Fort Stanwix, the Penns were allowed to purchase the modern region from the Iroquois.In 1784, Thomas Viceroy completed a town plan which was approved by the Penn family attorney.Pittsburgh became a possession of Pennsylvania in 1785.A 1769 survey referenced the future city as the "Manor of Pittsburgh".Both the Colony of Virginia and the Province of Pennsylvania claimed the region under their colonial charters until 1780, when they agreed under a federal initiative to extend the Mason–Dixon line westward, placing Pittsburgh in Pennsylvania.Lord Jeffery Amherst ordered blankets contaminated from smallpox victims to be distributed in 1763 to the tribes surrounding the fort.The disease spread into other areas, infected other tribes, and killed hundreds of thousands.British General Edward Braddock was dispatched with Major George Washington as his aide to take Fort Duquesne.The British and colonial force were defeated at Braddock's Field.